Systemic inflammatory profiles and their relationships with demographic, behavioural and clinical features in acute low back pain, 2016

Topics: Pro-inflammatory cytokines , C-reactive protein (CRP), Interleukin-6 (IL-6) , Tumor necrosis factor (TNF) , Interleukin-1beta (IL-1beta), Low back pain (LBP)

Authors: David M Klyne, Mary F Barbe, Paul W Hodges

Abstract

Systemic inflammation is linked with development and persistence of many pathological pain states. Although chronic phase inflammatory responses are well reported, the acute phase has received limited attention. Here we investigated circulating pro-inflammatory cytokines and C-reactive protein (CRP), and explored their relationships with symptom severity and other factors in acute low back pain (LBP). Ninety-nine individuals within two weeks of onset of acute LBP and 55 pain-free controls completed questionnaires related to their pain (visual analogue scale, VAS) and disability, behaviour, sleep quality and psychological status. CRP, interleukin-6 (IL-6), tumor necrosis factor (TNF) and interleukin-1b (IL-1b) were measured from serum samples. Biomarkers were compared between LBP and control partic- ipants, and in a separate analysis, for those with ‘‘high-pain” (VAS P4) and ‘‘low-pain” (VAS

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